tms and pharmacology

TMS and Pharmacology Helps Treatment- Resistant Depression

Depression. That one little word is responsible for so much suffering, so much despair. Unlike a common health condition where you just go to the doctor and receive medicine that will cure it, depression often defies treatment efforts. Depression continues to be a mysterious, complex mental health disorder that challenges the psychiatric community at large to discovery satisfactory answers.

While the conventional practice of prescribing antidepressant drug therapy has been effective for the majority of patients with depression, a significant number remain treatment resistant. This means that even after trialing several different antidepressants over a period of many months, the individual continues to experience the very discouraging symptoms of depression.

Since 2008, when the FDA cleared transcranial magnetic stimulation (TMS) for the treatment of individuals with refractory depression, an alternative route to remission has been carved out. TMS therapy offers a noninvasive, safe, and effective option for treatment-resistant depression that can be used either as a standalone treatment or can be combined with an antidepressant. Using TMS and pharmacology, the genetic testing that helps identify which antidepressant will be most effective in an individual, new inroads have been made in the battle against treatment-resistant depression.

About Depression

Although major depressive disorder (MDD) affects about 17 million U.S. adults per year, about a third of them never get the treatment they need. A stubborn stigma still surrounds mental health conditions, such as depression, acting as a barrier to getting needed help. Other barriers to care include lack of insurance coverage or other financial barriers, uncertainty about where to obtain mental health services, and inadequate screening by primary care physicians. Some people may not know where to even begin to get help and instead continue to suffer in silence. This only leads to a more entrenched mental health challenge, as well as increasing negative consequences in all areas of life resulting from the depression.

The DSM-5 criteria for diagnosing depression involves five or more of the following symptoms having been present most of the time for more than two weeks:

  1. Persistent sad mood, feelings of hopelessness and despair
  2. Recent unexplained weight gain or loss
  3. Difficulty concentrating or making decisions
  4. Change in sleep patterns, sleep dysfunction
  5. Fatigue
  6. Lack of interest in the activities once enjoyed
  7. Irrational feelings of guilt or shame
  8. Slowed thinking and motor skills
  9. Obsessing about death or suicide

The cause of MDD is still widely unknown, although science has identified several potential factors in developing clinical depression. These include genetics, temperament or personality traits, environmental factors, a co-occurring substance use disorder, medical conditions, and brain chemistry/biology.

TMS Explained

Treatment for depression can yield varying results. This uneven response rate is one of the most studied questions within the field of psychiatry, why one individual might respond to first-line depression treatment protocol while another does not. Fortunately, with the advent of TMS as a legitimate treatment tool for individuals with the treatment-resistant form of depression there is another way to approach this complicated mental health disorder.

TMS therapy is a brain stimulation technique that accesses the power of magnets through a technology closely associated with the MRI. Using a coil placed over the patient’s scalp, TMS administers the magnetic pulses, delivering this energy to the targeted brain region. There the magnetic energy induces electrical currents that work to stimulate the inactive or underactive neurons in the limbic region and central nervous system.

Over the period of 4-6 weeks, with the 40-minute treatment sessions scheduled 5 days per week the brain chemistry becomes rebalanced. This helps to normalize the symptoms that have plagued the patient, improving energy and focus, general mood, and sleep quality. TMS does not involve surgery, hospitalization, general anesthesia, or recovery time. The individual is free to drive immediately following the treatment session and can return to normal activities.

TMS therapy is a safe, drug-free alternative for individuals who cannot tolerate the side effects caused by antidepressants. For others who had only minimal response to the antidepressants, TMS, when used in tandem with the medication, can help to speed up the effects of the antidepressant.

More About Pharmacology

When someone seeks out help for their depression through their primary care physician, they will probably be assigned an antidepressant as the first step of treating the mood disorder. However, as happens in about half the patients, the medication may not perform. This leads the doctor to either prescribe a second antidepressant, or to refer the patient to a psychiatrist who has more extensive knowledge of the many antidepressants on the market and their particular nuances.

In recent years, the process of determining which antidepressant is the best fit for a given patient has been assisted through pharmacology using genetic testing. Pharmacology is simply the study of the process through which medication effects the body and its systems. The testing may reveal certain biological features that can help the psychiatrist narrow down the scope of which drug to prescribe.

How TMS and Pharmacology Help Pinpoint Treatment

When deciding to consider alternative methods of depression treatment, TMS therapy offers an excellent option. Some patients may have had a modicum of improvement on an antidepressant, and are looking to augment the clinical outcome by adding TMS therapy. Others may have not experienced any success with antidepressants and are seeking a drug-free alternative treatment for the depression.

If the individual, along with the psychiatrist, decides to continue on with antidepressant therapy and then combine it with TMS, it is helpful to use both TMS and pharmacology together to arrive at the best possible outcome. TMS can help activate the properties of the antidepressant, and in some cases augment its effects to the point where dosing can be reduced.

TMS Success Rates:

The evidence supporting the efficacy of TMS therapy for treatment of refractory depression continues to advance its credibility as a legitimate treatment option. Globally, clinical trials continue to be conducted on the many potential applications of TMS therapy, in addition to treatment resistant depression. Pertaining to the success rates of TMS therapy for major depressive disorder, consider these studies:

  • A meta-analysis published in JAMA Psychiatry included 81 randomized trials and concluded that the TMS treatment versus sham treatment were more effective regarding response rates.
  • This large multi-center study encompassed 42 clinical sites and treated 307 patients who had treatment-resistant depression. Using three clinical assessment tools to record changes in depression symptoms at baseline, week two, and week six of TMS treatment sessions, the results demonstrated statistically significant response and remission rates.
  • A meta-analysis of more than 100 published clinical trials of TMS for treatment of refractory depression produced a consensus that daily TMS treatments show substantial evidence of efficacy and safety for patients who are drug-resistant or intolerant to antidepressants.
  • A study with 212 participants using the Hamilton Depression Rating Scale (HDRS) to assess depression rates before and after a four-week TMS treatment protocol. Based on the change in the HDRS results, findings showed that the patients who received TMS had statistically significant higher remission rates than the sham treatments.

Combining Therapies for Better Success in Treating Depression

Increasingly, depression treatment is becoming more tailored. Antidepressants are no longer considered the be all and end all of depression treatment. More mental health practitioners are adding complementary therapies to the treatment plan, which can enhance overall treatment response. Because depression is so individualized, covering a broader range of territory through the various treatment options may increase remission rates overall. Here is a list of the various modes of treatment that can be considered for treatment of depression:

  • Medication: Psychotropic medications continue to represent the primary treatment mode for depressive disorders. The antidepressants are available in four different forms, including SSRIs, SNRIs, MAOIs, and tricyclics. Generally, antidepressants take 4-6 weeks to become efficacious. It is quite common for changes to be made in response to failed trials, involving either a change in dosing or a switch to a different drug.
  • Psychotherapy: Psychotherapy can be very useful to patients with depression. Through the individual or group sessions, the therapist can help guide the patient in examining underlying emotional issues that may be a factor. There are various evidence-based therapies that can help individuals delve into dysfunctional thought patterns or past traumas, or to just help them resolve recent setbacks.
  • TMS therapy: TMS is a neuromodulation technology that can help recalibrate brain chemistry and improve functioning. TMS is a safe, effective and noninvasive treatment option for depression, as well as depression with co-occurring anxiety.
  • Holistic therapy. Therapists now consider holistic methods to be an important piece of the treatment plan. These therapies can help patients regulate emotions and stress, while providing them with a calmer state of mind. Holistic therapies might include massage therapy, meditation, yoga, acupuncture, gardening, journaling, art therapy, mindfulness, and equine therapy.
  • Nutrition. The role of diet is also recognized as an essential aspect of recovery. Certain food choices can contribute to depression and should be avoided, such as refined sugars, processed foods and salty snacks, alcohol, and caffeinated beverages. Instead, eating a diet rich in omega-3 fatty acids, whole grains, seeds, and legumes, and fresh produce will assist in depression recovery.
  • Exercise. There is no disputing the importance of movement and activity in depression recovery. Just 3 or 4 30-minute to 60-minute workouts per week can produce a wide range of both mental and physical health benefits. Cardio workouts help stimulate the production of key brain chemicals that contribute to wellbeing, such as endorphins, dopamine, serotonin, and norepinephrine. Mental health benefits include improved mood, better sleep quality and more energy.

Anew Era TMS Offers Premier Depression Treatment Using TMS Therapy

Anew Era TMS provides expert TMS and psychiatric services in Southern California and Texas. As  part of a comprehensive program, TMS therapy can offer an additional tool in the treatment of stubborn treatment-resistant depression. Allow our dedicated doctors and staff to assist you in reclaiming your quality of life. Call Anew Era TMS today at (888) 503-1549.


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